Breast lesion size assessment in mastectomy specimens: Correlation of cone-beam breast-CT, digital breast tomosynthesis and full-field digital mammography with histopathology. Issue 37 (September 2019)

• Record Type: Journal Article
• Authors: Wienbeck, Susanne; Uhlig, Johannes; Fischer, Uwe; Hellriegel, Martin; von Fintel, Eva; Kulenkampff, Dietrich; Surov, Alexey; Lotz, Joachim; Perske, Christina
• Other Names: Aslam. Muhammad Shahzad section editor.
• Is Part Of: Medicine. Volume 98:Issue 37(2019)
• Publication Date: 2019-09
• Subjects: breast cancer -- cone-beam breast-CT -- digital breast tomosynthesis -- full-field digital mammography -- mastectomy specimens; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000017082
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: To compare the accuracy of breast lesion size measurement of cone-beam breast-CT (CBBCT), digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM). Patients scheduled for mastectomy due to at least 1 malignant breast lesion were included. Mastectomy specimens were examined by CBBCT, DBT, FFDM, and histopathology. A total of 94 lesions (40 patients) were included. Histopathological analyses revealed 47 malignant, 6 high-risk, and 41 benign lesions. Mean histopathological lesion size was 20.8 mm (range 2–100). Mean absolute size deviation from histopathology was largest for FFDM (5.3 ± 6.7 mm) and smallest for CBBCT 50 mA, high-resolution mode (4.3 ± 6.7 mm). Differences between imaging modalities did not reach statistical significance ( P = .85). All imaging methods tend to overestimate breast lesion size compared to histopathological gold standard. No significant differences were found regarding size measurements, although in tendency CBBCT showed better lesion detection and cT classification over FFDM.