Transformation of Monoclonal B Lymphocytosis to Epstein-Barr Virus–Positive Large B-Cell Lymphoma With Intermediate Features Between Diffuse Large B-cell Lymphoma and Classic Hodgkin Lymphoma. Issue 5 (September 2019)

• Record Type: Journal Article
• Authors: Liu, Ying; Ho, Caleb; Roshal, Mikhail; Baik, Jeeyeon; Arcila, Maria; Zhang, Yanming; Dogan, Ahmet; Xiao, Wenbin
• Is Part Of: AJSP reviews & reports. Volume 24:Issue 5(2019)
• Publication Date: 2019-09
• Subjects: chronic lymphocytic leukemia -- classic Hodgkin lymphoma -- Epstein-Barr virus+ diffuse large B-cell lymphoma -- monoclonal B-lymphocytosis -- Richter syndrome/transformation -- gray zone lymphoma; Pathology, Surgical -- Periodicals; Pathology, Surgical; Pathologie chirurgicale; Pathology, Surgical; Electronic journals; Periodicals; 617.07
• DOI: 10.1097/PCR.0000000000000326
• Languages: English
• ISSNs: 2381-5949

Abstract

Abstract : Abstract: Transformation of chronic lymphocytic leukemia (CLL) to an aggressive lymphoma, so-called Richter syndrome, usually includes diffuse large B-cell lymphoma and classic Hodgkin lymphoma. The transformation can be clonally related to the underlying CLL and is often Epstein-Barr virus (EBV) associated. Here we report the case of an 86-year-old woman with a newly identified CLL-like monoclonal B-lymphocytosis who developed diffuse lymphadenopathy. Biopsy of the left axillary lymph node showed EBV-positive large B-cell lymphoma with morphologic and immunophenotypic features intermediate between diffuse large B-cell lymphoma and classic Hodgkin lymphoma, so-called gray zone lymphoma. Comprehensive immunophenotypic, cytogenetic, and molecular studies demonstrate a clonal relatedness that suggests a transformation from monoclonal B-lymphocytosis to EBV + gray zone lymphoma.