Circulating miR-21 levels in hypertensive patients with asymptomatic organ damage. Issue 39 (September 2019)

• Record Type: Journal Article
• Authors: Yildirim, Erkan; Ermis, Emrah; Allahverdiyev, Samir; Ucar, Hakan; Yavuzer, Serap; Cengiz, Mahir
• Other Names: Vilela-Martin. José Fernando section editor.
• Is Part Of: Medicine. Volume 98:Issue 39(2019)
• Publication Date: 2019-09
• Subjects: asymptomatic organ damage -- hypertension -- miR-21; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000017297
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: As a modifiable risk factor for cardiovascular disease, presence of hypertension (HT) necessitates the awareness of asymptomatic organ damage (AOD). The aim of this study was to measure plasma micro RNA-21 (miR-21) and the parameters that reflect AOD such as carotid intima-media thickness (CIMT), microalbuminuria (MAU) in hypertensive patients compared with healthy controls. In addition, the aim of this study was to evaluate plasma miR-21 levels in HT patients with AOD. This study was designed as a cross-sectional observational study. The study includes 2 groups: 32 patients with HT and 32 healthy controls. First, we compared these 2 groups. Then, to underline the relationship between plasma miR-21 and HT, hypertensive patients were divided into 2 groups: with AOD and without AOD. Sixteen patients with HT had AOD. MiR-21 levels significantly correlated with clinical systolic and diastolic blood pressure, MAU, C-reactive protein, and CIMT. CIMT, miR-21, and MAU levels were significantly higher in patients with AOD. Our study showed increased miR-21 levels in HT patients with AOD.