Preparation of cationic polyelectrolyte grafted polyvinyl alcohol-formaldehyde macroporous hydrogels and their antibacterial properties. (6th September 2019)

• Record Type: Journal Article
• Authors: Yang, Xu; Sha, Di; Xu, Jiuduo; Niu, Niu; Shi, Kai; Pan, Yanxiong; Yu, Cong; Wei, Hua; Wang, Baolong; Ji, Xiangling
• Is Part Of: New journal of chemistry. Volume 43:Number 37(2019)
• Page Start: 14961
• Page End: 14971
• Publication Date: 2019-09-06
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c9nj03263k
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A series of novel antibacterial porous cationic PVF- g -PDMC hydrogels, synthesized by radical polymerization using ceric ammonium nitrate as an initiator, show excellent antibacterial properties, and can be used as biomedical materials. Abstract : Antibacterial hydrogels have the effects of creating a moist and cool environment for wound healing and decreasing infection of microbes, along with providing high water vapor permeability. Based on the functions of antibacterial hydrogels, macroporous PVF- g -PDMC cationic hydrogels, as one form of these hydrogels, were successfully synthesized via redox initiated [2-(methacryloyloxy)ethyl]-trimethyl ammonium chloride (DMC) grafting onto polyvinyl alcohol-formaldehyde (PVF) sponges. The interconnected pore channels of the as-prepared hydrogels, with a macroporous structure and high porosity of around 90%, conferred the hydrogels with remarkable water absorption capacity of up to 20 g g −1, achieved in ten seconds. Notably, the as-prepared hydrogels can kill Gram-negative ( E. coli and P. aeruginosa ) and Gram-positive ( S. aureus ) bacteria significantly, with a reduction of six orders of magnitude compared with the high initial concentration of bacteria (10 8 CFU mL −1 ), which indicates their excellent antibacterial properties. Moreover, the hemolysis and cytocompatibility studies confirmed the safety and biocompatibility of the hydrogels. Besides this, these PVF-based hydrogels also displayed prominent mechanical properties and their cyclic stress–strain curves demonstrate their good reusability. Considering their high porosity and extraordinary water absorption capacity of up to 20 g g −1 in ten seconds, antibacterial properties, low hemolysis rates and good cytocompatibility, prominent mechanical properties and good reusability, PVF- g -PDMC hydrogels are promising candidates as desirable antibacterial materials related to biomedical materials.