Hybrid isoquinolines from Thalictrum foetidum: a new type of aporphine inhibiting Staphylococcus aureus by combined mechanisms. Issue 19 (9th September 2019)

• Record Type: Journal Article
• Authors: Ding, Cai-Feng; Zhang, Rong-Ping; Yu, Hao-Fei; Yang, Jing; Qin, Xu-Jie; Dai, Zhi; Liu, Ya-Ping; Lu, Qiu-Min; Lai, Ren; Luo, Xiao-Dong
• Is Part Of: Organic chemistry frontiers. Volume 6:Issue 19(2019)
• Page Start: 3428
• Page End: 3434
• Publication Date: 2019-09-09
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c9qo00737g
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Thalfoetines A–D (1–4 ), unique hybrid aporphine alkaloids with a C-7 aromatic unit formed by a new C–C bond linking two building blocks, were isolated from Thalictrum foetidum . Abstract : Thalfoetines A–D (1–4 ), unique hybrid aporphine alkaloids with a C-7 aromatic unit formed by a new C–C bond linking two building blocks, were isolated from Thalictrum foetidum . Their structures were elucidated by extensive spectroscopic and computational analysis. They inhibited bacteria significantly, and compound 1 damaged the cell structure of Staphylococcus aureus and inhibited its DNA synthesis.