High-performance polarization control modulated surface plasmon resonance sensor based on monolayer graphene/Au-NPs architecture for detection of DNA hybridization. (16th September 2019)

• Record Type: Journal Article
• Authors: Sun, Yi; Cai, Haoyuan; Qiao, Xin; Wang, Xiaoping
• Is Part Of: Measurement science & technology. Volume 30:Number 12(2019:Dec.)
• Publication Date: 2019-09-16
• Subjects: plasmonic biosensor -- DNA hybridization -- graphene -- Au nanoparticles -- surface plasmon resonance; Physical measurements -- Periodicals; Scientific apparatus and instruments -- Periodicals; Equipment and Supplies -- Periodicals; Science -- instrumentation -- Periodicals; Technology -- instrumentation -- Periodicals; Mesures physiques -- Périodiques; Physical measurements; Scientific apparatus and instruments; Periodicals; 502.87
• DOI: 10.1088/1361-6501/ab383a
• Languages: English
• ISSNs: 0957-0233

Abstract

Abstract: A highly sensitive polarization control modulated plasmonic biosensor based on monolayer graphene/Au-NPs for direct detection of single-stranded DNA (ssDNA) hybridization is reported. The presence of monolayer graphene on gold film provides novel functionalized derivatives through π -stacking interactions. In addition, the online assembly strategy via in situ monitoring between ssDNA and Au-NPs makes the binding easier and quantifiable. The use of strong plasmon-mediated energy confinements induces an approximately 30-fold intense field enhancement of the reflected light. The architecture exhibits a linear dynamic range of 10 −15 to 10 −7 M for the detection of target ssDNA. Moreover, the new biosensor can achieve an ultralow detection limit of 500 aM for 23-mer ssDNA via improved sensitivity to molecular bindings.