Predictors of Major Bleeding and Mortality in Dengue Infection: A Retrospective Observational Study in a Tertiary Care Centre in South India. (4th September 2019)

• Record Type: Journal Article
• Authors: John, Kevin John; Gunasekaran, Karthik; Prasad, John Davis; Mathew, Divya; Das, Sohini; Sultan, N.; Abraham, Asha Mary; Iyyadurai, Ramya
• Other Names: Estrada-Franco Jose G. Academic Editor.
• Is Part Of: Interdisciplinary perspectives on infectious diseases. Volume 2019(2019)
• Publication Date: 2019-09-04
• Subjects: Communicable diseases -- Periodicals; 571.9805
• DOI: 10.1155/2019/4823791
• Languages: English
• ISSNs: 1687-708X

Abstract

Abstract : We conducted a retrospective observational study to describe the clinical profile and outcomes of patients admitted with a diagnosis of dengue fever in a tertiary hospital in South India. A total of 159 patients admitted from April 2014 to October 2018 were included in the study. Vomiting (70.4%), myalgia (60.4%), headache (42.1%), abdominal pain (38.4%), bleeding (38%), and rash (37.1%) were the most common symptoms at presentation. The mean duration of hospital stay was 4.9 days (SD ± 2.4), and the median cost was INR 19, 708 ($285) (IQR INR 12, 968–32, 056 ($188–$305)). Major bleeding was associated with elevated SGOT and SGPT, severe dengue, and secondary dengue. Mortality was associated with elderly age; elevated total leukocyte count, serum bilirubin, serum creatinine, SGOT, and SGPT; and high SOFA score. In view of these observations, we recommend stratifying patients according to the WHO classification of dengue and avoiding the use of thrombocytopenia as a single marker of the severity of the illness.