Bioprinters for organs-on-chips. (20th September 2019)

• Record Type: Journal Article
• Authors: Miri, Amir K; Mostafavi, Ebrahim; Khorsandi, Danial; Hu, Shu-Kai; Malpica, Matthew; Khademhosseini, Ali
• Is Part Of: Biofabrication. Volume 11:Number 4(2019)
• Publication Date: 2019-09-20
• Subjects: microfluidics -- bioprinting -- organ-on-chip -- multiscale; Biomedical engineering -- Periodicals; Tissue engineering -- Periodicals; Biomedical materials -- Microstructure -- Periodicals; Bioengineering -- Periodicals; 610.28
• DOI: 10.1088/1758-5090/ab2798
• Languages: English
• ISSNs: 1758-5082

Abstract

Abstract: Recent advances in bioprinting technologies have enabled rapid manufacturing of organ-on-chip models along with biomimetic tissue microarchitectures. Bioprinting techniques can be used to integrate microfluidic channels and flow connections in organ-on-chip models. We review bioprinters in two categories of nozzle-based and optical-based methods, and then discuss their fabrication parameters such as resolution, replication fidelity, fabrication time, and cost for micro-tissue models and microfluidic applications. The use of bioprinters has shown successful replicates of functional engineered tissue models integrated within a desired microfluidic system, which facilitates the observation of metabolism or secretion of models and sophisticated control of a dynamic environment. This may provide a wider order of tissue engineering fabrication in mimicking physiological conditions for enhancing further applications such as drug development and pathological studies.