Sensorimotor Connectivity after Motor Exercise with Neurofeedback in Post-Stroke Patients with Hemiplegia. (15th September 2019)

• Record Type: Journal Article
• Authors: Tsuchimoto, Shohei; Shindo, Keiichiro; Hotta, Fujiko; Hanakawa, Takashi; Liu, Meigen; Ushiba, Junichi
• Is Part Of: Neuroscience. Volume 416(2019)
• Page Start: 109
• Page End: 125
• Publication Date: 2019-09-15
• Subjects: brain-computer interface -- closed-loop brain training -- double-blinded trial -- randomized controlled study -- resting-state functional connectivity -- and sensorimotor reorganization; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2019.07.037
• Languages: English
• ISSNs: 0306-4522

Abstract

Abstract: Impaired finger motor function in post-stroke hemiplegia is a debilitating condition with no evidence-based or accessible treatments. Here, we evaluated the neurophysiological effectiveness of direct brain control of robotic exoskeleton that provides movement support contingent with brain activity. To elucidate the mechanisms underlying the neurofeedback intervention, we assessed resting-state functional connectivity with functional magnetic resonance imaging (rsfcMRI) between the ipsilesional sensory and motor cortices before and after a single 1-h intervention. Eighteen stroke patients were randomly assigned to crossover interventions in a double-blind and sham-controlled design. One patient dropped out midway through the study, and 17 patients were included in this analysis. Interventions involved motor imagery, robotic assistance, and neuromuscular electrical stimulation administered to a paretic finger. The neurofeedback intervention delivered stimulations contingent on desynchronized ipsilesional electroencephalographic (EEG) oscillations during imagined movement, and the control intervention delivered sensorimotor stimulations that were independent of EEG oscillations. There was a significant time × intervention interaction in rsfcMRI in the ipsilesional sensorimotor cortex. Post-hoc analysis showed a larger gain in increased functional connectivity during the neurofeedback intervention. Although the neurofeedback intervention delivered fewer total sensorimotor stimulations compared to the sham-control, rsfcMRI in the ipsilesional sensorimotor cortices was increased during the neurofeedback intervention compared to the sham-control. Higher coactivation of the sensory and motor cortices during neurofeedback intervention enhanced rsfcMRI in the ipsilesional sensorimotor cortices. This study showed neurophysiological evidence that EEG-contingent neurofeedback is a promising strategy to induce intrinsic ipsilesional sensorimotor reorganization, supporting the importance of integrating closed-loop sensorimotor processing at a neurophysiological level. Highlights: We assessed the neurophysiological effectiveness of direct brain control of neurofeedback intervention. The experiment was conducted with a crossover design with double-blinded outcome evaluation. Seventeen stroke patients with hemiplegia participated in this study. Neurofeedback intervention enhances resting-state functional connectivity on the ipsilesional sensorimotor cortices. Higher coactivation of the sensorimotor cortices during neurofeedback intervention enhanced the functional connectivity.