Meta‐inflammaging at the crossroad of geroscience. Issue 3 (8th September 2019)

• Record Type: Journal Article
• Authors: Chen, Guobing; Yung, Raymond
• Other Names: Leng Sean X. guestEditor.
• Is Part Of: Aging medicine. Volume 2:Issue 3(2019)
• Page Start: 157
• Page End: 161
• Publication Date: 2019-09-08
• Subjects: geroscience -- inflammaging -- metabolic inflammation; Geriatrics -- Periodicals; Geriatrics -- China -- Periodicals; Older people -- Diseases -- Periodicals; 618.97
• DOI: 10.1002/agm2.12078
• Languages: English
• ISSNs: 2475-0360

Abstract

Abstract: Geroscience posits that selected fundamental biological processes are the foundation of age‐related chronic diseases and are responsible for the decline in physical and mental function in old age. Late‐life chronic low‐grade inflammation ("inflammaging") and altered signal transduction pathways in metabolism have been identified as two of the key themes in the aging process. Age‐related changes in the immune and metabolic responses are also recognized as playing a critical pathogenic role in most common chronic medical conditions that plague the elderly. Emerging investigations emphasize the interconnectedness of the immune and metabolic responses in aging, an area of gerontological research that can be termed "meta‐inflammaging."