Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of Macaranga tanarius. (13th October 2019)

• Record Type: Journal Article
• Authors: Doan, Thi Mai Huong; Nguyen, Thuy Linh; Trinh, Thi Thanh Van; Vu, Van Nam; Phi, Thi Dao; Litaudon, Marc; Roussi, Fanny; Chau, Van Minh; Pham, Van Cuong
• Other Names: Moldoveanu Serban C. Academic Editor.
• Is Part Of: Journal of analytical methods in chemistry. Volume 2019(2019)
• Publication Date: 2019-10-13
• Subjects: Chemistry, Analytic -- Periodicals; Chemistry, Analytic -- Technique -- Periodicals; 543.05
• DOI: 10.1155/2019/2917032
• Languages: English
• ISSNs: 2090-8865

Abstract

Abstract : A new flavonoid, macatanarin D (1 ), together with five known stilbenes (2-6 ), was isolated from fruit glandular trichomes of Macaranga tanarius . Their structures were elucidated on the basis of spectroscopic methods and through comparison with data reported in the literature. All isolated compounds were evaluated for their cytotoxic activities against KB and MCF-7 cell lines. Compounds3, 4, and5 showed the strongest activities against both cell lines with IC50 values in the range of 0.03–0.12 μ M, and compound2 only showed a significant cytotoxicity against KB cell line (IC50 = 0.26 μ M) and a moderate cytotoxicity against MCF-7 (IC50 = 10.4 μ M). Compounds1 and6 showed weak cytotoxic activities against KB cell line with IC50 values of 29.3 and 24.7 μ M, respectively.