Intraoperative Strain Elastosonography in Brain Tumor Surgery. Issue 2 (28th November 2018)

• Record Type: Journal Article
• Authors: Prada, Francesco; Del Bene, Massimiliano; Rampini, Angela; Mattei, Luca; Casali, Cecilia; Vetrano, Ignazio Gaspare; Gennari, Antonio Giulio; Sdao, Silvana; Saini, Marco; Sconfienza, Luca Maria; DiMeco, Francesco
• Is Part Of: Operative neurosurgery. Volume 17:Issue 2(2019)
• Page Start: 227
• Page End: 236
• Publication Date: 2018-11-28
• Subjects: Intraoperative ultrasound -- Sonoelastography -- Strain elastography -- Glioma -- Brain tumor -- Tumor stiffness -- Intraoperative imaging; Nervous system -- Surgery -- Periodicals; 617.480590
• DOI: 10.1093/ons/opy323
• Languages: English
• ISSNs: 2332-4252

Abstract

Abstract: BACKGROUND: Sonoelastography is an ultrasound imaging technique able to assess mechanical properties of tissues. Strain elastography (SE) is a qualitative sonoelastographic modality with a wide range of clinical applications, but its use in brain tumor surgery has been so far very limited. OBJECTIVE: To describe the first large-scale implementation of SE in oncological neurosurgery for lesions discrimination and characterization. METHODS: We analyzed retrospective data from 64 patients aiming at (i) evaluating the stiffness of the lesion and of the surrounding brain, (ii) assessing the correspondence between B-mode and SE, and (iii) performing subgroup analysis for gliomas characterization RESULTS: (i) In all cases, we visualized the lesion and the surrounding brain with SE, permitting a qualitative stiffness assessment. (ii) In 90% of cases, lesion representations in B-mode and SE were superimposable with identical morphology and margins. In 64% of cases, lesion margins were sharper in SE than in B-mode. (iii) In 76% of cases, glioma margins were sharper in SE than in B-mode. Lesions morphology/dimensions in SE and in B-mode were superimposable in 89%. Low-grade (LGG) and high-grade (HGG) gliomas were significantly different in terms of stiffness and stiffness contrast between tumors and brain, LGG appearing stiffer while HGG softer than brain (all P < ·001). A threshold of 2.5 SE score had 85.7% sensitivity and 94.7% specificity in differentiating LGG from HGG. CONCLUSION: SE allows to understand mechanical properties of the brain and lesions in examination and permits a better discrimination between different tissues compared to B-mode. Additionally, SE can differentiate between LGG and HGG.