Molecular-based Testing for Sexually Transmitted Infections Using Samples Previously Collected for Vaginitis Diagnosis. (2nd August 2018)

• Record Type: Journal Article
• Authors: Van Der Pol, Barbara; Daniel, Grace; Kodsi, Salma; Paradis, Sonia; Cooper, Charles K
• Is Part Of: Clinical infectious diseases. Volume 68:Number 3(2019)
• Page Start: 375
• Page End: 381
• Publication Date: 2018-08-02
• Subjects: vaginitis -- sexually transmitted infection -- coinfection -- molecular test -- diagnosis; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciy504
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Background: Vaginal symptoms are a leading cause of primary care visits for women. Individuals exhibiting symptoms often receive laboratory testing based on clinic-specific standards of care. Thus, women seen at a family practice clinic might only receive a vaginitis workup, whereas those seen at a sexually transmitted diseases clinic could be more likely to receive only sexually transmitted infection (STI) testing. Methods: The likelihood of STIs was assessed in women from whom samples were tested for vaginitis using a molecular diagnostic assay. Positivity rates for Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis DNA, detected using the BD MAX CT/GC/TV assay, were calculated. Concordance between the BD MAX Vaginal Panel and the BD MAX CT/GC/TV assay for detection of T. vaginalis was determined. Results: Women with bacterial vaginosis alone or with concurrent Candida spp infections had high rates of coinfection with sexually transmitted infections (24.4%–25.7%); samples from women who were negative for vaginitis had significantly lower positivity rates (7.9%; P < .001). Trichomonas vaginalis results were concordant between the BD MAX Vaginal Panel and the BD MAX CT/GC/TV assay in 559 of 560 samples tested. Conclusions: These data suggest, as have other studies, that women with vaginitis symptoms may be at risk for an STI. Molecular testing could provide broad diagnostic coverage for symptomatic women and improve patient management, regardless of the type of clinic in which patients are treated. Abstract : Vaginitis and sexually transmitted infection (STI) coinfection may be more common than previously acknowledged. Findings here suggest an increased association of STI with vaginitis in a screening population. Molecular testing for both vaginitis and STI could improve diagnostic information obtained by screening.