The Role of Cannabis in the Management of Inflammatory Bowel Disease: A Review of Clinical, Scientific, and Regulatory Information: Commissioned by the Crohn's and Colitis Foundation. Issue 3 (24th October 2018)

• Record Type: Journal Article
• Authors: Swaminath, Arun; Berlin, Eric P; Cheifetz, Adam; Hoffenberg, Ed; Kinnucan, Jami; Wingate, Laura; Buchanan, Sarah; Zmeter, Nada; Rubin, David T
• Is Part Of: Inflammatory bowel diseases. Volume 25:Issue 3(2019)
• Page Start: 427
• Page End: 435
• Publication Date: 2018-10-24
• Subjects: cannabis -- marijuana -- THC -- Crohn's disease -- ulcerative colitis -- inflammatory bowel disease; Inflammatory bowel diseases -- Periodicals; Colitis, Ulcerative -- Periodicals; Crohn Disease -- Periodicals; Inflammatory Bowel Diseases -- Periodicals; 616.344
• DOI: 10.1093/ibd/izy319
• Languages: English
• ISSNs: 1078-0998

Abstract

Abstract: There is significant interest among patients and providers in using cannabis (marijuana) and its derivatives to treat a number of chronic illnesses, including inflammatory bowel disease. Despite the Schedule I classification of cannabis by the federal government, state governments have sought ways to make cannabis available for specific medical conditions, and some states have legalized cannabis outright. This white paper summarizes the preclinical data, clinical data, safety data, and the regulatory landscape as they apply to medical cannabis use in inflammatory bowel disease. Animal models of cannabinoid chemistry and physiology give evidence of anti-inflammatory, antidiarrheal, and nociceptive-limiting properties. Human studies have found benefit in controlling symptoms and improving quality of life, but no studies have established true disease modification given the absent improvement in biomarker profiles or endoscopic healing. Finally, this review describes the legal, regulatory, and practical hurdles to studying the risks and benefits of medical cannabis in the United States.