A hemodynamic network involving the insula, the cingulate, and the basal forebrain correlates with EEG synchronization phases of sleep instability. Issue 4 (19th December 2018)

• Record Type: Journal Article
• Authors: Kokkinos, Vasileios; Vulliémoz, Serge; Koupparis, Andreas M; Koutroumanidis, Michalis; Kostopoulos, George K; Lemieux, Louis; Garganis, Kyriakos
• Is Part Of: Sleep. Volume 42:Issue 4(2019)
• Publication Date: 2018-12-19
• Subjects: EEG-fMRI -- cyclic alternating pattern -- sleep -- insula -- cingulate -- basal forebrain; Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsy259
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: The cyclic alternating pattern (CAP) encompasses the pseudoperiodic appearance of synchronized brain waves and rhythms and is considered a regulator of the nonrapid eye movement (NREM) sleep vigilance level, reflecting sleep instability. To determine the brain regions responsible for this phenomenon, we scored and analyzed sleep functional magnetic resonance imaging data acquired with simultaneous electroencephalography (EEG-fMRI). Group analysis revealed a set of brain areas showing statistically significant blood oxygen-level dependent signal correlated positively with the synchronization phase of the CAP, most prominent being the insula, the middle cingulate gyrus, and the basal forebrain. These areas may form a network acting as a synchronization pacemaker, controlling the level of NREM sleep vigilance and the sleeper's arousability.