Venous Thromboembolism in Patients With Spontaneous Intracerebral Hemorrhage: A Multicenter Study. Issue 6 (13th July 2018)

• Record Type: Journal Article
• Authors: Ding, Dale; Sekar, Padmini; Moomaw, Charles J; Comeau, Mary E; James, Michael L; Testai, Fernando; Flaherty, Matthew L; Vashkevich, Anastasia; Worrall, Bradford B; Woo, Daniel; Osborne, Jennifer
• Is Part Of: Neurosurgery. Volume 84:Issue 6(2019)
• Page Start: E304
• Page End: E310
• Publication Date: 2018-07-13
• Subjects: Deep vein thrombosis -- Intracerebral hemorrhage -- Intracranial hemorrhages -- Pulmonary embolism -- Stroke -- Venous thromboembolism; Nervous system -- Surgery -- Periodicals; 617.48005
• DOI: 10.1093/neuros/nyy333
• Languages: English
• ISSNs: 0148-396X

Abstract

Abstract: BACKGROUND: Patients with spontaneous intracerebral hemorrhage (ICH) are predisposed to venous thromboembolic (VTE) complications, such as deep vein thrombosis and pulmonary embolism. OBJECTIVE: To evaluate, in a multicenter, retrospective cohort study, the rate of VTE complications in ICH patients during acute hospitalization, identify potential risk factors, and assess their association with functional outcome. METHODS: We retrospectively analyzed prospectively collected data from 19 centers and 41 sites that participated in the Ethnic/Racial Variations of Intracerebral Hemorrhage study, from August 2010 to February 2016. We compared ICH patients with VTE complications to those without VTE complications. Statistical analyses were performed to determine predictors of VTE complications and poor outcome (modified Rankin Scale ≥ 4) at discharge and 3-mo follow-up. RESULTS: Of the 2902 ICH patients who were eligible for analysis, 87 (3.0%) had VTE complications: 57 (2.0%) had only deep vein thrombosis, 19 (0.7%) had only pulmonary embolism, and 11 (0.4%) had both. In the multivariable logistic regression analysis, a prior history of VTE (odds ratio [OR] = 6.8; P < .0001), intubation (OR = 4.0; P < .0001), and presence of IVH (OR = 1.8; P = .0157) were independent predictors of VTE complications. After controlling for ICH volume and location, IVH, age, and presenting Glasgow Coma Scale, the occurrence of VTE complications was an independent predictor of poor outcome at discharge (OR = 2.9; P = .002) and 3-mo follow-up (OR = 2.1; P = .02). CONCLUSION: Although VTE complications are uncommon after ICH, they are associated with significantly worse outcomes. Further studies will be needed to determine the optimal treatment regimen for the prevention and treatment of VTE complications in ICH patients. Graphical Abstract: