Repurposing the anthelminthic salicylanilide oxyclozanide against susceptible and clinical resistant Candida albicans strains. (14th May 2018)

• Record Type: Journal Article
• Authors: Pic, Emilie; Burgain, Anaïs; Sellam, Adnane
• Is Part Of: Medical mycology. Volume 57(2019)Supplement 3
• Page Start: 387
• Page End: 390
• Publication Date: 2018-05-14
• Subjects: antifungal activity -- salicylanilides -- oxyclozanide -- Candida -- antifungal resistance; Medical mycology -- Periodicals; Veterinary mycology -- Periodicals; Mycology -- Periodicals; Mycoses -- Periodicals; Pathogenic fungi -- Periodicals; 616.969005
• DOI: 10.1093/mmy/myy027
• Languages: English
• ISSNs: 1369-3786

Abstract

Abstract: Current antifungal drugs suffer from limitations including toxicity, adverse interactions with other commonly prescribed drugs, and the emergence of resistant strains. Here, we repurposed the anthelmintic oxyclozanide as a potent antifungal agent against both sensitive and resistant clinical isolates of Candida albicans, as well as other human opportunistic fungi. Antifungal activity of oxyclozanide was enhanced when C. albicans grew in nonfermentable carbon sources. Our data support a mechanism of action where oxyclozanide uncoupled the mitochondrial electron transport from oxidative phosphorylation and perturbed the mitochondrial membrane potential.