Regional GABA Concentrations Modulate Inter-network Resting-state Functional Connectivity. (28th March 2018)

• Record Type: Journal Article
• Authors: Chen, Xi; Fan, Xiaoying; Hu, Yuzheng; Zuo, Chun; Whitfield-Gabrieli, Susan; Holt, Daphne; Gong, Qiyong; Yang, Yihong; Pizzagalli, Diego A; Du, Fei; Ongur, Dost
• Is Part Of: Cerebral cortex. Volume 29:Number 4(2019)
• Page Start: 1607
• Page End: 1618
• Publication Date: 2018-03-28
• Subjects: anti-correlation -- default mode network -- fMRI -- GABA -- glutamate; Cerebral cortex -- Periodicals; Brain -- Periodicals; 612.825
• DOI: 10.1093/cercor/bhy059
• Languages: English
• ISSNs: 1047-3211

Abstract

Abstract: Coordinated activity within and differential activity between large-scale neuronal networks such as the default mode network (DMN) and the control network (CN) is a critical feature of brain organization. The CN usually exhibits activations in response to cognitive tasks while the DMN shows deactivations; in addition, activity between the two networks is anti-correlated at rest. To address this issue, we used functional MRI to measure whole-brain BOLD signal during resting-state and task-evoked conditions, and MR spectroscopy (MRS) to quantify GABA and glutamate concentrations, in nodes within the DMN and CN (MPFC and DLPFC, respectively) in 19 healthy individuals at 3 Tesla. We found that GABA concentrations in the MPFC were significantly associated with DMN deactivation during a working memory task and with anti-correlation between DMN and CN at rest and during task performance, while GABA concentrations in the DLPFC weakly modulated DMN–CN anti-correlation in the opposite direction. Highlighting specificity, glutamate played a less significant role related to brain activity. These findings indicate that GABA in the MPFC is potentially involved in orchestrating between-network brain activity at rest and during task performance.