Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood. (18th April 2018)

• Record Type: Journal Article
• Authors: Albaugh, Matthew D; Ivanova, Masha; Chaarani, Bader; Orr, Catherine; Allgaier, Nicholas; Althoff, Robert R; D' Alberto, Nicholas; Hudson, Kelsey; Mackey, Scott; Spechler, Philip A; Banaschewski, Tobias; Brühl, Rüdiger; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Cattrell, Anna; Conrod, Patricia J; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Gallinat, Jürgen; Goodman, Robert; Gowland, Penny; Grimmer, Yvonne; Heinz, Andreas; Kappel, Viola; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Penttilä, Jani; Poustka, Luise; Paus, Tomáš; Smolka, Michael N; Struve, Maren; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Garavan, Hugh; Potter, Alexandra S;
• Is Part Of: Cerebral cortex. Volume 29:Number 5(2019)
• Page Start: 1866
• Page End: 1874
• Publication Date: 2018-04-18
• Subjects: attention-deficit/hyperactivity disorder -- neuroimaging -- ventromedial prefrontal cortex; Cerebral cortex -- Periodicals; Brain -- Periodicals; 612.825
• DOI: 10.1093/cercor/bhy066
• Languages: English
• ISSNs: 1047-3211

Abstract

Abstract: Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated with ventromedial prefrontal cortex (vmPFC) structure. Herein, we investigate the degree to which vmPFC structure during adolescence predicts hyperactive/inattentive symptomatology at 5-year follow-up. Structural equation modeling was used to test the extent to which adolescent vmPFC volume predicts hyperactive/inattentive symptomatology 5 years later in early adulthood. 1104 participants ( M = 14.52 years, standard deviation = 0.42; 583 females) possessed hyperactive/inattentive symptom data at 5-year follow-up, as well as quality controlled neuroimaging data and complete psychometric data at baseline. Self-reports of hyperactive/inattentive symptomatology were obtained during adolescence and at 5-year follow-up using the Strengths and Difficulties Questionnaire (SDQ). At baseline and 5-year follow-up, a hyperactive/inattentive latent variable was derived from items on the SDQ. Baseline vmPFC volume predicted adult hyperactive/inattentive symptomatology (standardized coefficient = −0.274, P < 0.001) while controlling for baseline hyperactive/inattentive symptomatology. These results are the first to reveal relations between adolescent brain structure and adult hyperactive/inattentive symptomatology, and suggest that early structural development of the vmPFC may be consequential for the subsequent expression of hyperactive/inattentive symptoms.