Effect of remifentanil infusion on the hemodynamic response during induction of anesthesia in hypertensive and normotensive patients: a prospective observational study. Issue 12 (December 2019)

• Record Type: Journal Article
• Authors: Lee, Soo Kyung; Jeong, Mi Ae; Sung, Jeong Min; Yeon, Hyo Jin; Chang, Ji Hee; Lim, Hyunyoung
• Is Part Of: Journal of international medical research. Volume 47:Issue 12(2019)
• Page Start: 6254
• Page End: 6267
• Publication Date: 2019-12
• Subjects: General anesthesia -- hemodynamic changes -- hypertension -- remifentanil -- tracheal intubation -- systolic blood pressure -- diastolic blood pressure; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/0300060519883568
• Languages: English
• ISSNs: 0300-0605

Abstract

Background: The induction of general anesthesia may cause hemodynamic instability. Remifentanil is often administered to suppress the hemodynamic response. We aimed to evaluate the effect of remifentanil infusion on the hemodynamic response to induction of anesthesia in hypertensive and normotensive patients. Methods: Patients were divided into two groups: Group H (n = 102) were hypertensive patients and Group C (n = 107) were normotensive patients. During induction, all patients received 1 µg/kg of remifentanil as a loading dose over 2 minutes, followed by a continuous infusion at 0.05 µg/kg/minute. We analyzed the systolic, diastolic, and mean pressures and heart rate pre-induction, pre-intubation, immediately post-intubation, and at 2, 4, 6, 8, and 10 minutes after intubation. Results: The systolic, diastolic, and mean pressures before induction were significantly higher in group H compared with group C, but there was no significant difference between the two groups immediately after intubation. Blood pressures immediately after intubation were similar to the pre-induction blood pressure. There was no significant difference in heart rate between the two groups at any time point. Conclusions: Remifentanil infusion effectively attenuates the hemodynamic response to induction of general anesthesia in hypertensive and normotensive patients.