Pleomorphic Mantle Cell Lymphoma of the Tongue Base Presenting With Dysphagia. Issue 12 (February 2019)

• Record Type: Journal Article
• Authors: Ryan, Marisa A; Cheng, Tracy; Yoo, David S; Fisher, Samuel R
• Is Part Of: Clinical medicine insights. Issue 12(2019)
• Publication Date: 2019-02
• Subjects: B-cell lymphoma -- non-Hodgkin lymphoma -- pleomorphic mantle cell lymphoma -- oropharyngeal lymphoma -- tongue base lymphoma; Otolaryngology -- Periodicals; Otorhinolaryngologic Diseases; Otolaryngology; Otolaryngology; Electronic journals; Periodicals; Fulltext; Internet Resources; Periodicals; Periodicals; 617.51005
• DOI: 10.1177/1179550619831058
• Languages: English
• ISSNs: 1179-5506

Abstract

Objectives: We aim to increase awareness of pleomorphic mantle cell lymphoma as a rare, but aggressive form of lymphoma with propensity for recurrence in secondary locations. Methods: We report the case of a 70-year-old man who presented with chronic post-nasal drainage, dysphagia, and voice changes caused by a tongue base mass. Results: Partial excision and pathology showed a pleomorphic mantle cell lymphoma, and radiation treatment was completed. A regional recurrence was detected 3 years later and treated with radiation. He had no evidence of disease 17 months after treatment of the recurrence and is under close surveillance. Conclusions: Pleomorphic mantle cell lymphoma is an aggressive subtype of non-Hodgkin lymphoma that can affect the head and neck. Confirming the diagnosis with immunotyping and genotyping from fresh specimens can guide appropriate treatment and then close clinical follow-up.