Body mass index, comorbidities, and hormonal factors in relation to meningioma in an ethnically diverse population: the Multiethnic Cohort. Issue 4 (6th January 2019)

• Record Type: Journal Article
• Authors: Muskens, Ivo S; Wu, Anna H; Porcel, Jacqueline; Cheng, Iona; Le Marchand, Loïc; Wiemels, Joseph L; Setiawan, Veronica Wendy
• Is Part Of: Neuro-oncology. Volume 21:Issue 4(2019)
• Page Start: 498
• Page End: 507
• Publication Date: 2019-01-06
• Subjects: cohort study -- meningioma -- multiethnic cohort; Brain Neoplasms -- Periodicals; Brain -- Tumors -- Periodicals; Brain -- Cancer -- Periodicals; Nervous system -- Cancer -- Periodicals; 616.99481
• DOI: 10.1093/neuonc/noz005
• Languages: English
• ISSNs: 1522-8517

Abstract

Abstract: Background: Meningioma is the most common intracranial tumor in the US and its etiology remains poorly understood. Meningioma has been predominantly studied among white populations. The aim of this study was to evaluate the associations of anthropometric, comorbidity, and hormonal factors with meningioma in an ethnically diverse population. Methods: A nested case-control analysis was performed within the Multiethnic Cohort (MEC). Meningioma cases were identified via linkage with Medicare and the California Office of Statewide Health Planning and Development Hospital Discharge data and were matched to up to 10 controls. Anthropometric, comorbidities, physical activity level, and hormonal factors at baseline based on questionnaires were evaluated for association with meningioma. Results: A total of 894 cases and 8918 matched controls were included in this study. Increasing body mass index (BMI) (P-trend = 0.041) and weight increases since age 21 (P-trend = 0.0052) were positively associated with meningioma. Hormonal factors including oral contraceptive use (odds ratio [OR]: 1.24; 95% CI: 1.01–1.51) and estrogen hormonal therapy use (per 5 years, OR: 1.07; 95% CI: 1.01–1.15) were associated with meningioma risk. Hypertension was positively associated with meningioma (OR: 1.26; 95% CI: 1.09–1.47), with individuals who reported a history of both hypertension and diabetes showing a stronger association (OR: 1.54; 95% CI: 1.17–2.03). The tests for heterogeneity across race/ethnicity were not statistically significant (P heterogeneity ≥ 0.17); however, the association of BMI with meningioma was mainly observed in Japanese Americans (P-trend = 0.0036) and hypertension in Japanese Americans (OR: 1.63; 95% CI: 1.17–2.27) and Native Hawaiians (OR: 1.86; 95% CI: 1.02–3.40). Conclusion: Obesity, hormonal factors, and hypertension were associated with meningioma in an ethnically diverse population.