Regulation of collagen type XVII expression by miR203a-3p in oral squamous cell carcinoma cells. (27th March 2019)

• Record Type: Journal Article
• Authors: Yasukochi, Atsushi; Kawakubo-Yasukochi, Tomoyo; Morioka, Masahiko; Hazekawa, Mai; Nishinakagawa, Takuya; Ono, Kazuhiko; Nakashima, Manabu; Nakamura, Seiji
• Is Part Of: Journal of biochemistry. Volume 166:Number 2(2019)
• Page Start: 163
• Page End: 173
• Publication Date: 2019-03-27
• Subjects: collagen 17 -- miR203a-3p -- oral squamous cell carcinoma -- p53 -- tumour progression; Biochemistry -- Periodicals; Biochemistry -- Periodicals; Electronic journals; 572.05
• DOI: 10.1093/jb/mvz024
• Languages: English
• ISSNs: 0021-924X

Abstract

Abstract: Collagen type XVII (COL17) is expressed in various tissues and its aberrant expression is associated with tumour progression. In this study, we investigated the regulation of COL17 expression in oral squamous cell carcinoma (OSCC) using the cell lines NA, SAS, Ca9-22, and Sa3. COL17 was induced upon p53 activation by cisplatin in SAS; however, this effect was more limited in NA and hardly in Ca9-22 and Sa3, with mutated p53. Moreover, COL17 was found to be regulated by miR203a-3p in all cell lines. Our data suggest that COL17 expression in OSCC cell lines is regulated by p53 and miR203a-3p.