Intratumoral IL17-producing cells infiltration correlate with antitumor immune contexture and improved response to adjuvant chemotherapy in gastric cancer. (15th November 2018)

• Record Type: Journal Article
• Authors: Wang, J T; Li, H; Zhang, H; Chen, Y F; Cao, Y F; Li, R C; Lin, C; Wei, Y C; Xiang, X N; Fang, H J; Zhang, H Y; Gu, Y; Liu, X; Zhou, R J; Liu, H; He, H Y; Zhang, W J; Shen, Z B; Qin, J; Xu, J J
• Is Part Of: Annals of oncology. Volume 30:Number 2(2019)
• Page Start: 266
• Page End: 273
• Publication Date: 2018-11-15
• Subjects: IL17-producing cells -- immune contexture -- prognosis -- adjuvant chemotherapy -- gastric cancer; Oncology -- Periodicals; 616.992
• DOI: 10.1093/annonc/mdy505
• Languages: English
• ISSNs: 0923-7534

Abstract

Abstract: Background: Tumor IL17-producing (IL17A + ) cells infiltration has different prognostic values among various cancers. The objective of this study was to assess the effect of IL17A + cells in gastric cancer. Patients and methods: The study included two patient cohorts, the Cancer Genome Atlas cohort ( TCGA, n = 351) and the Zhongshan Hospital cohort ( ZSHC, n = 458). The TCGA and ZSHC were used for mRNA-related and cells infiltration-related analyses, respectively. The roles of IL17A mRNA and IL17A + cells in overall survival (OS), response to adjuvant chemotherapy (ACT), and immune contexture were evaluated. Another independent cohort was included to identify the correlation between mRNA of IL17A and IL17A + cells infiltration (the preliminary Zhongshan Hospital cohort, PZSHC, n = 21). Results: The infiltration of IL17A + cells was positively correlated with the expression of IL17A mRNA (Spearman's ρ = 0.811; P < 0.001). High IL17A mRNA expression and intratumoral IL17A + cells were correlated with improved OS and remained to be significant after adjusted for confounders. Patients with TNM II/III disease whose tumor present higher intratumoral IL17A + cells or lower peritumoral IL17A + cells can benefit more from ACT. Elevated IL17A mRNA expression and increased intratumoral IL17A + cells infiltration was associated with more antitumor mast cells and nature killer cells infiltration and less pro-tumor M2 macrophages infiltration. High IL17A mRNA expression represented a Th17 cells signature and immune response process and was correlated with increased cytotoxic GZMA, GZMB, IFNG, PRF1, and TNFSF11 expression. Conclusions: IL17A mRNA expression and intratumoral IL17A + cells infiltration were correlated with antitumor immune contexture. IL17A + cells infiltration could be used as an independent prognostic biomarker for OS and predictive biomarker for superior response to ACT, and further prospective validation needs to be conducted.