Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barré Syndrome. (3rd August 2018)

• Record Type: Journal Article
• Authors: Lynch, Rebecca M; Mantus, Grace; Encinales, Liliana; Pacheco, Nelly; Li, Guangzhao; Porras, Alexandra; Mendoza, Alejandro R; Peng, Jin; Rengifo-Pardo, Monica; Cruz, Magelda Montoya; Harris, Eva; Bethony, Jeff M; Simon, Gary L; Chang, Aileen Y
• Is Part Of: Journal of infectious diseases. Volume 219:Number 1(2019)
• Page Start: 26
• Page End: 30
• Publication Date: 2018-08-03
• Subjects: Guillain-Barré syndrome -- neutralizing antibody -- flavivirus -- Zika -- dengue; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiy466
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection. Abstract : We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia and found that high neutralizing antibody titers to dengue virus and Zika virus (ZIKV) were associated with Guillain-Barré syndrome during ZIKV infection.