Incidence of Cancer and Infertility, in Patients Treated for Adolescent Idiopathic Scoliosis 25 Years Prior. Issue 1 (April 2016)

• Record Type: Journal Article
• Authors: Simony, Ane; Carreon, Leah Y.; Christensen, Steen Bach; Andersen, Mikkel Ø.
• Is Part Of: Global spine journal. Volume 6:Issue 1(2016)Supplement
• Page Start: s-0036-1582918
• Page End: s-0036-1582918
• Publication Date: 2016-04
• Subjects: Spine -- Diseases -- Periodicals; Spine -- Diseases -- Treatment -- Periodicals; Spine -- Abnormalities -- Periodicals; Spine -- Surgery -- Periodicals; 616.73
• DOI: 10.1055/s-0036-1582918
• Languages: English
• ISSNs: 2192-5682

Abstract

Introduction: Adolescent females with idiopathic scoliosis are exposed to substantial amounts of radiation during treatment and follow-up for AIS. The purpose of this study was to determine the amount radiation exposure patients received during treatment for AIS and report the incidence of infertility and cancer in adulthood. Material and Method: 219 consecutive AIS patients treated at Rigshospitalet, Copenhagen between 1983 and 1990 were identified and requested to return for clinical and radiographic examination. The incidence of cancer was determined through chart review and follow-up interviews. In addition, the subjects and age-matched controls were queried regarding infertility, age at first pregnancy and spontaneous abortions. Using X -ray reports that included patient position, mAs and kV used and the number of X-rays taken, a radiation physicist calculated the total radiation dose during treatment and follow-up adjusted for BMI and sex. Results: 159 (78%) patients participated in the follow up study, and medical charts were available in 209 patients. 2 patients had passed away, one due to cardiac arrest and one to breast cancer. 8 patients had emigrated. Radiation information was available in 211 patients. The mean calculated mean total radiation exposure was 1.58 mSv (0, 44–6, 9). An average of 16.3 (range, 8–34) X-rays were taken during treatment. The rate of infertility (10%) and spontaneous abortion (23%) is similar to the normal controls. The AIS patients had an average of 1.4 children, which is 1 child less than the 2.5 children in the control cohort. Nine (4.3%) AIS patients developed cancer, mostly breast (3) and endometrial (4). Risk Ratio for cancer = 20.93 (95% CI:2.67–164.19) p = 0.000132. The patients with endometrial cancers have a low BMI 16.4 (15.9–16.6) at first radiation exposure, and the patients with breast cancers were older with BMI 20.4 (18.0–22.4). The incidence of cancer in this cohort is 17 times greater than the incidence of 0.25% in an age-sex matched cohort from the Danish Cancer Society Annual Report. Conclusion: The infertility and spontaneous abortion rate was similar between AIS patients and an age matched cohort. The cancer rate in the AIS patients is 17 times higher than expected compared with the age-matched Danish population. Table 1 Summary of demographic characteristics AIS patients Controls Total *Both patient and partner infertile. N 165 100 Responders 95 (57, 6%) 65 (65%) Female 91 59 Age at end of treatment 14, 3 years (12–18 years) Age at questionnaire 37, 6 years (33–47 years) 37, 5 years (26–54 years) Have you been pregnant 85 (89, 5%) 54 (91, 5%) Infertility 11* (10, 6%) 8 (12, 3%) Partner infertile 6* (6, 3%) 5 (7, 6%) Spontaneous abortion 22 (22, 9%) 14 (21, 5%) Age at 1 pregnancy 23, 0 years (16–41 years) 26, 0 years (20–40 years) N of children 1, 4 (1–4 children) 2, 5 (1–4 children) Table 2 Summary of demographic characteristics AIS patients N 219 Data available 209* Female 199 Age at follow-up 37, 6 years (33–47 years) BMI at treatment 19, 56 (12, 26–27, 85) N X-rays during treatment 16, 3 (8–34) Radiation dose pr exam 0, 8–1, 4 mSv Cummulative radiation dose per year 2, 4–5, 6 mSv Number of cancer 9 Endometrial cancer 4 Breast cancer 3 Lymphoma 1 Glioma 1