Comparison of the Effectiveness of High-Intensity Interval Training in Hypoxia and Normoxia in Healthy Male Volunteers: A Pilot Study. (22nd September 2019)

• Record Type: Journal Article
• Authors: Żebrowska, Aleksandra; Jastrzębski, Dariusz; Sadowska-Krępa, Ewa; Sikora, Marcin; Di Giulio, Camillo
• Other Names: Sawaguchi Toshiyuki Academic Editor.
• Is Part Of: BioMed research international. Volume 2019(2019)
• Publication Date: 2019-09-22
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2019/7315714
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Aims . The study investigated the effect of high-intensity interval training in hypoxia and normoxia on serum concentrations of proangiogenic factors, nitric oxide, and inflammatory responses in healthy male volunteers. Methods . Twelve physically active male subjects completed a high-intensity interval training (HIIT) in normoxia (NorTr) and in normobaric hypoxia (HypTr) (FiO2 = 15.2%). The effects of HIIT in hypoxia and normoxia on maximal oxygen uptake, hypoxia-inducible factor-1-alpha, vascular endothelial growth factor, nitric oxide, and cytokines were analyzed. Results . HIIT in hypoxia significantly increases maximal oxygen uptake (p = 0.01 ) levels compared to pretraining levels. Serum hypoxia-inducible factor-1 (p = 0.01 ) and nitric oxide levels (p = 0.05 ), vascular endothelial growth factor (p = 0.04 ), and transforming growth factor- β (p = 0.01 ) levels were increased in response to exercise test after hypoxic training. There was no effect of training conditions for serum baseline angiogenic factors and cytokines (p > 0.05 ) with higher HIF-1 α and NO levels after hypoxic training compared to normoxic training ( F = 9.1;p < 0.01 and F = 5.7;p < 0.05, respectively). Conclusions . High-intensity interval training in hypoxia seems to induce beneficial adaptations to exercise mediated via a significant increase in the serum concentrations of proangiogenic factors and serum nitric oxide levels compared to the same training regimen in normoxia.