An aminophosphonate ester ligand-containing platinum(ii) complex induces potent immunogenic cell death in vitro and elicits effective anti-tumour immune responses in vivo. Issue 87 (1st October 2019)

• Record Type: Journal Article
• Authors: Huang, Ke-Bin; Wang, Feng-Yang; Feng, Hai-Wen; Luo, Hejiang; Long, Yan; Zou, Taotao; Chan, Albert S. C.; Liu, Rong; Zou, Huahong; Chen, Zhen-Feng; Liu, Yan-Cheng; Liu, You-Nian; Liang, Hong
• Is Part Of: Chemical communications. Volume 55:Issue 87(2019)
• Page Start: 13066
• Page End: 13069
• Publication Date: 2019-10-01
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc06563f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A platinum(ii )-aminophosphonate complex (Pt1 ) induces potent anti-tumour immunogenic cell death (ICD) in vitro and in vivo . Abstract : A platinum(ii ) complex containing an aminophosphonate ligand preferentially accumulates in the endoplamic reticulum (ER) in association with potent ER stress and reactive oxygen species generation, followed by the activation of damage-associated molecular pattern signals and immune responses. Importantly, the Pt complex exhibits potent anti-tumour activities in two independent mouse models via an immunogenic cell death pathway.