D–A polymers for fluorescence/photoacoustic imaging and characterization of their photothermal properties. Issue 42 (7th October 2019)

• Record Type: Journal Article
• Authors: Zhu, Yaowei; Gu, Chuantao; Miao, Yawei; Yu, Bing; Shen, Youqing; Cong, Hailin
• Is Part Of: Journal of materials chemistry. Volume 7:Issue 42(2019)
• Page Start: 6576
• Page End: 6584
• Publication Date: 2019-10-07
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c9tb01196j
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Two D–A polymers with good NIR-II fluorescence, photoacoustic and photothermal properties were designed and synthesized. Abstract : NIR-II fluorescence imaging has great potential in diagnosis, but the quantum efficiency of contrast agents is an urgent problem to be solved. We synthesized two new multifunctional polymers, P-TT and P-DPP, with a tetrahedral C (sp 3 ) and branched alkyl chains in the main chain, which were beneficial to obtain high quantum efficiency. P-TT and P-DPP showed absorption peaks of 686 nm and 763 nm, respectively, and fluorescence emission peaks of 1071 nm and 1066 nm, respectively. The photothermal effect of P-DPP can reach 52 °C, and the quantum yield reaches 1.5%, which was three times higher than that of nanotube fluorophores (quantum yield 0.4%). P-DPP is used for stable fluorescence imaging of blood vessels and photoacoustic imaging of nude mice, and successfully applied to phototherapy of nude mouse tumours.