Engineering graphene oxide with ultrasmall SPIONs and smart drug release for cancer theranostics. Issue 13 (25th January 2019)

• Record Type: Journal Article
• Authors: Luo, Yu; Tang, Yan; Liu, Tianzhi; Chen, Qian; Zhou, Xiaohan; Wang, Ning; Ma, Ming; Cheng, Yingsheng; Chen, Hangrong
• Is Part Of: Chemical communications. Volume 55:Issue 13(2019)
• Page Start: 1963
• Page End: 1966
• Publication Date: 2019-01-25
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc09185d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An intelligent nanoplatform is constructed by conjugating cis -aconitic anhydride-modified doxorubicin to weakly crystallized, ultrasmall SPION loaded graphene oxide (GO) nanosheets. More importantly, the composites present ultrasensitive breakage hydrolysis induced by pH alteration, achieving on-demand, gradual drug release in the tumor microenvironment. Abstract : A smart nanotheranostics nanoplatform was constructed using engineered graphene oxide and the in situ growth of ultrasmall superparamagnetic iron oxide particles (SPIONs). The construction of such a novel theranostics nanoplatform shows great potential in tumor theranostics, especially for T 1 -weighted magnetic resonance ( T 1 -MR) imaging guided, pH-sensitive chemotherapy.