Photo-induced formation of organic nanoparticles possessing enhanced affinities for complexing nerve agent mimics. Issue 13 (28th January 2019)

• Record Type: Journal Article
• Authors: Border, Sarah E.; Pavlović, Radoslav Z.; Zhiquan, Lei; Gunther, Michael J.; Wang, Han; Cui, Honggang; Badjić, Jovica D.
• Is Part Of: Chemical communications. Volume 55:Issue 13(2019)
• Page Start: 1987
• Page End: 1990
• Publication Date: 2019-01-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc08938h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Organic nanoparticles, composed of molecular baskets, could act as nanocarriers for selective "mopping" of toxic CWAs or pesticides, after being assembled by a light stimulus. Abstract : Molecular baskets 1 6− –3 6−, functionalized with α-amino acids at their rim, undergo photo-induced α-decarboxylations to give amphiphilic 4 3− –6 3− assembling into nanoparticles. Nanoparticulate 4 3− –6 3− possess greater affinities for complexing OPs (akin to sarin and cyclosarin) than monomeric 1 6− –3 6− . With the ability of nanoparticles to function in urine, our study sets the stage for creating novel nanocarriers capable of spatiotemporal sequestration of nerve agents or pesticides in competitive chemical environments.