Tumor‐derived exosomes modulate T cell function through transfer of RNA. (23rd March 2018)

• Record Type: Journal Article
• Authors: House, Imran G.; Petley, Emma V.; Beavis, Paul A.
• Is Part Of: FEBS journal. Volume 285:Number 6(2018)
• Page Start: 1030
• Page End: 1032
• Publication Date: 2018-03-23
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; 572
• DOI: 10.1111/febs.14413
• Languages: English
• ISSNs: 1742-464X

Abstract

Abstract : Tumor cells can develop a variety of mechanisms to evade and subvert the immune system for their survival. Bland et al ., in this edition of The FEBS Journal, make the novel finding that the tumor line B16F0 can deliver mRNA/miRNA loaded exosomes to cytotoxic T lymphocytes and alter their metabolic function and interferon gamma production.