Mammalian mitophagy – from in vitro molecules to in vivo models. (1st December 2017)

• Record Type: Journal Article
• Authors: Rodger, Catherine E.; McWilliams, Thomas G.; Ganley, Ian G.
• Is Part Of: FEBS journal. Volume 285:Number 7(2018)
• Page Start: 1185
• Page End: 1202
• Publication Date: 2017-12-01
• Subjects: autophagy -- development -- disease -- metabolism -- mitochondria -- mitophagy -- mito‐QC -- mouse models -- NIX -- Parkin; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; 572
• DOI: 10.1111/febs.14336
• Languages: English
• ISSNs: 1742-464X

Abstract

Abstract : The autophagic turnover of mitochondria, termed mitophagy, is thought to play an essential role in not only maintaining the health of the mitochondrial network but also that of the cell and organism as a whole. We have come a long way in identifying the molecular components required for mitophagy through extensive in vitro work and cell line characterisation, yet the physiological significance and context of these pathways remain largely unexplored. This is highlighted by the recent development of new mouse models that have revealed a striking level of variation in mitophagy, even under normal conditions. Here, we focus on programmed mitophagy and summarise our current understanding of why, how and where this takes place in mammals. Abstract : Mitophagy, the autophagic degradation of mitochondria, is a complex process that plays key roles in maintaining mitochondrial homeostasis and cellular health. In this review, we summarise the mechanisms that regulate mitophagy in vitro and discuss the advent of new mouse models that are allowing us to place such mechanisms into a physiological context.