Cancer Radiotherapy: Enhanced Radiosensitization by Gold Nanoparticles with Acid‐Triggered Aggregation in Cancer Radiotherapy (Adv. Sci. 8/2019). Issue 8 (17th April 2019)

• Record Type: Journal Article
• Authors: Zhang, Yumin; Huang, Fan; Ren, Chunhua; Liu, Jinjian; Yang, Lijun; Chen, Shizhu; Chang, Jinglin; Yang, Cuihong; Wang, Weiwei; Zhang, Chuangnian; Liu, Qiang; Liang, Xing‐Jie; Liu, Jianfeng
• Is Part Of: Advanced science. Volume 6:Issue 8(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-04-17
• Subjects: aggregation -- gold nanoparticles -- pH responsiveness -- radiosensitizers -- tumor retention; Science -- Periodicals; 505
• DOI: 10.1002/advs.201970050
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract : In article number1801806, Xing‐Jie Liang, Jianfeng Liu, and co‐workers develop a gold nanoparticles (GNPs) system with acid‐triggered aggregation as a radiosensitizer. With a sensitizer enhancement ratio (SER) value of 1.730 (vs. single GNPs of 1.16), this GNPs system improves sensitivity of MCF‐7 cells and MCF‐7 tumor xenograft to ionizing radiation. This work provides a strategy for fabricating radiosensitizer by in situ acid‐triggered nano‐aggregates formation.