68Ga-PSMA-11 PET/MR Can Be False Positive in Normal Prostatic Tissue. (April 2019)

• Record Type: Journal Article
• Authors: Ferraro, Daniela A.; Rupp, Niels J.; Donati, Olivio F.; Messerli, Michael; Eberli, Daniel; Burger, Irene A.
• Is Part Of: Clinical nuclear medicine. Volume 44:Number 4(2019)
• Publication Date: 2019-04
• Subjects: 68Ga-PSMA -- PET/MR -- false positive -- prostate cancer; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000002473
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein expressed in the cytosol of normal prostate tissue and highly overexpressed on the membrane of prostate cancer, therefore increasingly used to image prostate cancer. We report a case of a 65-year-old man with two focal PSMA-positive areas on a 68 Ga-PSMA-11 PET/MR, one corresponding to a prostate carcinoma (Gleason score 4 + 3) and another region without any evidence of malignancy, but with corresponding high PSMA-expression on immunohistochemistry.