Diverse mechanisms of IRF5 action in inflammatory responses. (June 2018)

• Record Type: Journal Article
• Authors: Khoyratty, Tariq E.; Udalova, Irina A.
• Is Part Of: International journal of biochemistry & cell biology. Volume 99(2018)
• Page Start: 38
• Page End: 42
• Publication Date: 2018-06
• Subjects: IRF5 -- Myeloid cells -- Inflammation -- Transcription; Biochemistry -- Periodicals; Cytology -- Periodicals; Biochemistry -- Periodicals; Cell Biology -- Periodicals; Biochimie -- Périodiques; Cytologie -- Périodiques; Biochimie; Cytologie; Biochemistry; Cytology; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); Periodicals; 572.05
• DOI: 10.1016/j.biocel.2018.03.012
• Languages: English
• ISSNs: 1357-2725

Abstract

Abstract: Interferon regulatory factor 5 (IRF5) is a key signal-dependent transcription factor in myeloid cells. Its expression is induced by granulocyte-macrophage colony stimulating factor and interferon-gamma. IRF5 protein is further activated in response to stimulation, translocating to the nucleus where it mediates inflammatory responses. IRF5 is capable of both the up-regulation of pro-inflammatory genes and repressing anti-inflammatory mediators, thus polarising macrophages to a pro-inflammatory phenotype. We discuss IRF5 interactions with a wide range of transcriptional regulators that give rise to its diverse effects at the level of chromatin.