Polymers and organic materials-based pH sensors for healthcare applications. (July 2018)

• Record Type: Journal Article
• Authors: Alam, Arif Ul; Qin, Yiheng; Nambiar, Shruti; Yeow, John T.W.; Howlader, Matiar M.R.; Hu, Nan-Xing; Deen, M. Jamal
• Is Part Of: Progress in materials science. Volume 96(2018)
• Page Start: 174
• Page End: 216
• Publication Date: 2018-07
• Subjects: ALD atomic layer deposition -- BCB divinyltetramethyldisiloxane-bis(benzocyclobutene) -- BGOFET back-gated organic field effect transistor -- BSD budesonide -- CMOS complementary metal-oxide semiconductor -- CNT carbon nanotube -- CuPc copper(II) phthalocyanine -- CVD chemical vapor deposition -- CYTOP cyclized perfluoro polymer -- DA-BEDA N, N′-dialkylbenzylethylenediamine -- DDFTTF 5, 5′-bis-(7-dodecyl-9H-fluoren-2-yl)-2, 2′-bithiophene -- DNA deoxyribonucleic acid -- DPV differential pulse voltammetry -- EBL electron-beam lithography -- EDL electrical double layer -- EGFET electrolyte-gated field-effect transistor -- EGOFET electrolyte-gated organic field-effect transistor -- EGOFET electrolyte-gated organic field-effect transistor -- EPPG edge plane pyrolytic graphite -- ExGOFET extended-gate organic field-effect transistor -- FET field-effect transistor -- FGOFET floating-gate organic field-effect transistor -- FITC fluorescein isothiocyanate -- FRET fluorescence resonance energy transfer -- HDA 4, 4-(hexafluoroisopropylidene)diphthalic anhydride -- HEK human embryonic kidney cells -- HeLa cervical cancer cells -- HFCVD hot filament chemical vapor deposition -- HQS hydroquinone monosulfonate -- IJP ink-jet printing -- IS-EGOFET ion-sensitive electrolyte-gated organic field-effect transistor -- ISFET ion-sensitive field-effect transistor -- ISM ion sensitive membrane -- ISOFET ion-sensitive organic field-effect transistors -- LB Langmuir-Blodgett -- LCP liquid crystal polymer -- MWCNT multi-walled carbon nanotubes -- NIL nano-imprint lithography -- OECT organic electrochemical transistor -- OFET organic field-effect transistor -- OTFT organic thin film transistors -- P3CT poly(3-cyclohexyl thiophene) -- P3HT poly(3-hexylthiophene) -- P3MT poly(3-methylthiophene) -- PAA poly(1-aminoanthracene) -- PAH poly-(allylamine hydrochloride) -- PANI polyanilline -- PB prussian blue -- PBPA polybisphenol A -- PCz polycarbazole -- PDAN poly-1, 5-diaminonaphthalene -- PDAEM poly(2-dimethylaminoethyl methacrylates) -- PEAA polyethylacrylic Acid -- PEDOT:PSS poly(3, 4-ethylenedioxythiophene) polystyrene sulfonate -- PEI polyethylenimine -- PEN polyethylene naphthalate -- PET polyethylene terephthalate -- PGA polyglycolic acid -- PI polyimide -- PLGA poly(lactic-co-glycolic) -- PMMA poly(methyl methacrylate) -- PPAA poly(propyl acrylic acid) -- PPI polypropylenimine -- PPPD poly(p-phenylenediamine) -- PPy polypyrrole -- PTAA poly(triarylamine) -- PVA polyvinyl alcohol -- PVC polyvinyl chloride -- PVP poly(4-vinylphenol) -- SAM self-assembled monolayer -- SC suberoyl chloride -- SGOFET solution-gated organic field effect transistor -- siRNA small interfering RNA -- SWCNT single-walled carbon nanotube -- TBAP tetrabutylammonium perchlorate -- TPB tetraphenylborate -- α-6T α-sexithiophene; Polymers and organic materials -- Fabrication -- Electrochemical -- Electrical field-effect -- pH sensors -- Biomedical applications; Materials science -- Periodicals; Science des matériaux -- Périodiques; 620.1105
• DOI: 10.1016/j.pmatsci.2018.03.008
• Languages: English
• ISSNs: 0079-6425

Abstract

Abstract: In this review, we discuss chemical, physical and electrochemical properties of pH-sensitive polymers and organic materials and their sensing mechanisms for healthcare applications. We find that polymers and organic materials, due to their biocompatibility and customizable electrical and electrochemical properties, can be used in pH sensors as structural, pH-sensitive, and passivation materials. To do so, we first identify the properties and sensing mechanisms for pH-sensitive polymers and organic materials. Different functional groups in the materials determine their chemical properties and are involved in redox reactions for chemical sensing of pH. The transport of charge carriers in the polymers and organic materials is influenced by pH-induced electrical field change, which is responsible for physical sensing of pH. Some polymers and organic materials also show hybrid sensing properties, where both functional groups and electrical field-effect contribute to their pH response. Next, we review fabrication technologies for polymers and organic materials, and identify that engineering the materials and new device structures are two possible approaches to improve the sensitivity and reliability of pH sensing devices. We propose that miniaturized sensors can provide enhanced functionality of the sensing materials in constrained spaces. Finally, we present an overview of biocompatible polymers and organic materials for monitoring of pH and pH-related analytes in biological fluids, and for pH-change-triggered drug delivery.