Rh(III)‐Catalyzed Selective C8−H Acylmethylation of Quinoline N‐Oxides. Issue 21 (13th September 2018)

• Record Type: Journal Article
• Authors: You, Chang; Pi, Chao; Wu, Yangjie; Cui, Xiuling
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 21(2018)
• Page Start: 4068
• Page End: 4072
• Publication Date: 2018-09-13
• Subjects: C8−H bond activation -- acylmethylation -- quninoline N-oxide -- rhodium-catalyzed; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201800659
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A highly efficient Rh‐catalyzed regioselective C8−H acylmethylation of quinoline N‐ oxides with sulfoxonium ylides using N‐ oxide as the directing group under air atmosphere has been developed. This transformation has the generality of a broad scope of substrates, avoids external oxidants, and provides an efficient protocol to C8−H acylmethylated quinolines. Abstract :