Assessment of an Objective Method of Dyskinesia Measurement in Parkinson's Disease. Issue 2 (2nd March 2018)

• Record Type: Journal Article
• Authors: Chung, Kathryn A.; Lobb, Brenna M.; Murchison, Charles F.; Mancini, Martina; Hogarth, Penelope; Nutt, John G.
• Is Part Of: Movement disorders clinical practice. Volume 5:Issue 2(2018)
• Page Start: 160
• Page End: 164
• Publication Date: 2018-03-02
• Subjects: dyskinesia -- levodopa -- Parkinson disease -- validation; Movement Disorders; Movement disorders -- Periodicals; Movement disorders; Periodicals; Periodicals; 616
• DOI: 10.1002/mdc3.12583
• Languages: English
• ISSNs: 2330-1619

Abstract

Abstract: Background: The goal of this study was to validate an objective method of measuring levodopa induced dyskinesia in Parkinson's disease (PD). Methods: To characterize agreement between the clinician‐based measure and a force plate, we assessed dyskinesia in PD subjects participating in a randomized and blinded clinical trial of an adenosine A2A anatagonist. Convergent validity and intra‐class correlations were evaluated between the objective force plate measure and clinician assessments. Results: All measures correlated across time and detected differences in treatments. Conclusion: Our results indicate that objective measure from a force plate is in scale agreement with clinical ratings of dyskinesia severity, indicating it as a reliable method to measure LID objectively but with greater resolution to detect changes in LID.