Boron Trichloride‐Mediated Synthesis of Indoles via the Aminoboration of Alkynes. Issue 21 (7th September 2018)

• Record Type: Journal Article
• Authors: Lv, Jiahang; Zhao, Binlin; Liu, Li; Han, Ying; Yuan, Yu; Shi, Zhuangzhi
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 21(2018)
• Page Start: 4054
• Page End: 4059
• Publication Date: 2018-09-07
• Subjects: indole -- cyclization -- aminoboration -- alkynes -- catalyst-free; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201800509
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: We describe an efficient catalyst‐ and metal‐free aminoboration of alkynes to 3‐borylated indoles using one of the least expensive boron sources, BCl3 . The major dichloro(indolyl)borane products can be used for the in situ construction of useful 3‐Bpin indoles. This simple and mild method provides a novel and efficient approach for the synthesis of various 3‐borylated indoles with high regioselectivity and a wide substrate scope. Abstract :