Evaluating the Association between Enlarged Perivascular Spaces and Disease Worsening in Multiple Sclerosis. Issue 3 (11th December 2017)

• Record Type: Journal Article
• Authors: Cavallari, Michele; Egorova, Svetlana; Healy, Brian C.; Palotai, Miklos; Prieto, Juan Carlos; Polgar‐Turcsanyi, Mariann; Tauhid, Shahamat; Anderson, Mark; Glanz, Bonnie; Chitnis, Tanuja; Guttmann, Charles R.G.
• Is Part Of: Journal of neuroimaging. Volume 28:Issue 3(2018)
• Page Start: 273
• Page End: 277
• Publication Date: 2017-12-11
• Subjects: Progressive multiple sclerosis -- perivascular space -- Virchow‐Robin -- vascular -- CLIMB study; Diagnostic imaging -- Periodicals; Nervous system -- Diseases -- Diagnosis -- Periodicals; Imagerie pour le diagnostic -- Périodiques; Système nerveux -- Maladies -- Diagnostic -- Périodiques; Imagerie médicale; Neuroimagerie; Neurologie; Système nerveux; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.804754
• DOI: 10.1111/jon.12490
• Languages: English
• ISSNs: 1051-2284

Abstract

ABSTRACT: BACKGROUND AND PURPOSE: Enlarged perivascular spaces (EPVSs) have been associated with relapses and brain atrophy in multiple sclerosis (MS). We investigated the association of EPVS with clinical and MRI features of disease worsening in a well‐characterized cohort of relapsing‐remitting MS patients prospectively followed for up to 10 years. METHODS: Baseline EPVSs were scored on 1.5T MRI in 30 converters to moderate‐severe disability, and 30 nonconverters matched for baseline characteristics. RESULTS: EPVS scores were not significantly different between converters and nonconverters, nor associated with accrual of lesions or brain atrophy. CONCLUSIONS: Our preliminary findings from a relatively small study sample argue against a potential use of EPVS as early indicator of risk for disease worsening in relapsing‐remitting MS patients in a clinical setting. Although the small sample size and clinical 1.5T MRI may have limited our ability to detect a significant effect, we provided estimates of the association of EPVS with clinical and MRI indicators of disease worsening in a well‐characterized cohort of MS patients.