Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial. Issue 4 (24th February 2018)

• Record Type: Journal Article
• Authors: Chondronikola, Maria; Magkos, Faidon; Yoshino, Jun; Okunade, Adewole L.; Patterson, Bruce W.; Muehlbauer, Michael J.; Newgard, Christopher B.; Klein, Samuel
• Is Part Of: Obesity. Volume 26:Issue 4(2018)
• Page Start: 683
• Page End: 688
• Publication Date: 2018-02-24
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.22129
• Languages: English
• ISSNs: 1930-7381

Abstract

Abstract : Objective: Lactate is an intermediate of glucose metabolism that has been implicated in the pathogenesis of insulin resistance. This study evaluated the relationship between glucose kinetics and plasma lactate concentration ([LAC]) before and after manipulating insulin sensitivity by progressive weight loss. Methods: Forty people with obesity (BMI = 37.9 ± 4.3 kg/m 2 ) were randomized to weight maintenance ( n = 14) or weight loss ( n = 19). Subjects were studied before and after 6 months of weight maintenance and before and after 5%, 11%, and 16% weight loss. A hyperinsulinemic‐euglycemic clamp procedure in conjunction with [6, 6‐ 2 H2 ]glucose tracer infusion was used to assess glucose kinetics. Results: At baseline, fasting [LAC] correlated positively with endogenous glucose production rate (r = 0.532; P = 0.001) and negatively with insulin sensitivity, assessed as the insulin‐stimulated glucose disposal (r = −0.361; P = 0.04). Progressive (5% through 16%) weight loss caused a progressive decrease in fasting [LAC], and the decrease in fasting [LAC] after 5% weight loss was correlated with the decrease in endogenous glucose production (r = 0.654; P = 0.002) and the increase in insulin sensitivity (r = −0.595; P = 0.007). Conclusions: This study demonstrates the interrelationships among weight loss, hepatic and muscle glucose kinetics, insulin sensitivity, and [LAC], and it suggests that [LAC] can serve as an additional biomarker of glucose‐related insulin resistance.