Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores. Issue 15 (14th February 2019)

• Record Type: Journal Article
• Authors: Megarity, Clare F.; Siritanaratkul, Bhavin; Heath, Rachel S.; Wan, Lei; Morello, Giorgio; FitzPatrick, Sarah R.; Booth, Rosalind L.; Sills, Adam J.; Robertson, Alexander W.; Warner, Jamie H.; Turner, Nicholas J.; Armstrong, Fraser A.
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 15(2019)
• Page Start: 4948
• Page End: 4952
• Publication Date: 2019-02-14
• Subjects: cofactor recycling -- electrocatalysis -- ferredoxin NADP+ reductase -- nanoconfinement -- nicotinamide; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201814370
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: In living cells, redox chains rely on nanoconfinement using tiny enclosures, such as the mitochondrial matrix or chloroplast stroma, to concentrate enzymes and limit distances that nicotinamide cofactors and other metabolites must diffuse. In a chemical analogue exploiting this principle, nicotinamide adenine dinucleotide phosphate (NADPH) and NADP + are cycled rapidly between ferredoxin–NADP + reductase and a second enzyme—the pairs being juxtaposed within the 5–100 nm scale pores of an indium tin oxide electrode. The resulting electrode material, denoted (FNR+E2)@ITO/support, can drive and exploit a potentially large number of enzyme‐catalysed reactions. Abstract : In close quarters : Nicotinamide adenine dinucleotide phosphate (NADPH) and NADP + are cycled rapidly between ferredoxin–NADP + reductase (FNR) and a dehydrogenase enzyme (E2) within the 5–100 nm pores of an indium tin oxide electrode. The electrode mimics the nanoconfinement strategies of natural systems, such as the chloroplast stroma or mitochondria in living cells.