Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores. (14th February 2019)

• Record Type: Journal Article
• Authors: Megarity, Clare F.; Siritanaratkul, Bhavin; Heath, Rachel S.; Wan, Lei; Morello, Giorgio; FitzPatrick, Sarah R.; Booth, Rosalind L.; Sills, Adam J.; Robertson, Alexander W.; Warner, Jamie H.; Turner, Nicholas J.; Armstrong, Fraser A.
• Is Part Of: Angewandte Chemie. Volume 131:Number 15(2019)
• Page Start: 5002
• Page End: 5006
• Publication Date: 2019-02-14
• Subjects: Elektrokatalyse -- Ferredoxin-NADP+-Reduktase -- Kofaktor-Rezyklierung -- Nanoumgebung -- Nicotinamid; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201814370
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: In living cells, redox chains rely on nanoconfinement using tiny enclosures, such as the mitochondrial matrix or chloroplast stroma, to concentrate enzymes and limit distances that nicotinamide cofactors and other metabolites must diffuse. In a chemical analogue exploiting this principle, nicotinamide adenine dinucleotide phosphate (NADPH) and NADP + are cycled rapidly between ferredoxin–NADP + reductase and a second enzyme—the pairs being juxtaposed within the 5–100 nm scale pores of an indium tin oxide electrode. The resulting electrode material, denoted (FNR+E2)@ITO/support, can drive and exploit a potentially large number of enzyme‐catalysed reactions.