Biologics and stem cell‐based therapies for rotator cuff repair. Issue 1 (15th July 2018)

• Record Type: Journal Article
• Authors: Bianco, Spencer T.; Moser, Helen L.; Galatz, Leesa M.; Huang, Alice H.
• Editors: Sun, Hui B.
• Is Part Of: Annals of the New York Academy of Sciences. Volume 1442:Issue 1(2019)
• Page Start: 35
• Page End: 47
• Publication Date: 2018-07-15
• Subjects: rotator cuff -- tendon -- injury -- stem cells; Medical sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; 610
• DOI: 10.1111/nyas.13918
• Languages: English
• ISSNs: 0077-8923

Abstract

Abstract: The rotator cuff is composed of several distinct muscles and tendons that function in concert to coordinate shoulder motion. Injuries to these tendons frequently result in permanent dysfunction and persistent pain. Despite considerable advances in operation techniques, surgical repair alone still does not fully restore rotator cuff function. This review focuses on recent research in the use of biologics and stem cell‐based therapies to augment repair, highlighting promising avenues for future work and remaining challenges. While a number of animal models are used for rotator cuff studies, the anatomy of the rotator cuff varies dramatically between species. Since the rodent rotator cuff shares the most anatomical features with the human, this review will focus primarily on rodent models to enable consistent interpretation of outcome measures. Abstract : Injuries to the tendons of the rotator cuff frequently result in permanent dysfunction and persistent pain. This review focuses on recent research in the use of biologics and stem cell‐based therapies to augment surgical repair of the rotator cuff, highlighting promising avenues for future work and remaining challenges. Since the rodent rotator cuff shares the most anatomical features with the human, this review will focus primarily on rodent models to enable consistent interpretation of outcome measures.