Synthesis and biological activity of an Anderson polyoxometalate bis‐functionalized with a Bombesin‐analog peptide. Issue 5 (7th March 2018)

• Record Type: Journal Article
• Authors: Ventura, Daniele; Calderan, Andrea; Honisch, Claudia; Krol, Silke; Serratì, Simona; Bonchio, Marcella; Carraro, Mauro; Ruzza, Paolo
• Other Names: Morelli Giancarlo guestEditor.; Rovero Paolo guestEditor.; Toniolo Claudio guestEditor.
• Is Part Of: Peptide science. Volume 110:Issue 5(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-03-07
• Subjects: anticancer activity -- demobensin‐1 -- polyoxometalates -- POM‐peptide hybrid; Peptides -- Periodicals; 572.6505
• DOI: 10.1002/pep2.24047
• Languages: English
• ISSNs: 2475-8817

Abstract

Abstract: Polyoxometalates (POMs) are multi metallic and polyanionic oxides whose functionalization with organic moieties can generate new properties. Among possible strategies to generate molecular diversity and find applications in different fields, the postfunctionalization of a POM with peptides is particularly interesting and easily achievable. In this article, we present the functionalization of the Anderson‐Evans polyoxomolybdate ([MnMo6 O24 ] 3– ) with a Bombesin antagonist peptide, to highlight the interplay between these 2 domains, in terms of structural changes and assembly. Moreover, since Bombesin analogs show a marked binding affinity and specificity for some subtypes of the Gastrin Releasing Peptide Receptor (GRP‐R), the impact of the peptide on the antitumor activity of the Anderson‐Evans polyoxomolybdate POM has been explored. Abstract :