Possible role of airway microvascular permeability on airway obstruction in patients with chronic obstructive pulmonary disease. (January 2019)

• Record Type: Journal Article
• Authors: Kyomoto, Yohkoh; Kanazawa, Hiroshi; Tochino, Yoshihiro; Watanabe, Tetsuya; Asai, Kaziuhisa; Kawaguchi, Tomoya
• Is Part Of: Respiratory medicine. Volume 146(2019)
• Page Start: 137
• Page End: 141
• Publication Date: 2019-01
• Subjects: Airway microvascular system -- Bronchoscopic microsampling technique -- Chronic obstructive pulmonary disease -- Epithelial lining fluid -- Peripheral airways; AMPI airway microvascular permeability index -- COPD chronic obstructive pulmonary disease -- ELF epithelial lining fluid -- FEV1 forced expiratory volume in 1 s -- FVC forced vital capacity -- DLCO diffusing capacity of the lung for carbon monoxide; Chest -- Diseases -- Periodicals; Chest -- Diseases -- Great Britain -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Appareil respiratoire -- Maladies -- Périodiques; Thorax -- Maladies -- Périodiques; Appareil respiratoire -- Maladies -- Traitement -- Périodiques; Electronic journals; 616.2
• DOI: 10.1016/j.rmed.2018.12.007
• Languages: English
• ISSNs: 0954-6111

Abstract

Abstract: Background: Airway microvascular system participates in the airway inflammation that is central to the pathophysiology of inflammatory lung disorders. Objective: To examine the role of airway microvascular permeability on airway obstruction in patients with chronic obstructive pulmonary disease (COPD). Methods: We measured the airway microvascular permeability index (AMPI) separately in the central or peripheral airways using a bronchoscopic microsampling technique in 9 non-smokers, 18 smokers without COPD (10 former smokers and 8 current smokers), and 26 smokers with COPD (12 former smokers and 14 current smokers). Results: AMPI in the central airways was relatively low, and this index was comparable among the five groups. In contrast, AMPI in the peripheral airways was significantly higher in smokers with or without COPD compared with non-smokers. Moreover, AMPI in the peripheral airways was significantly higher in current smokers than in former smokers with COPD. Especially, AMPI in the peripheral airways, but not in the central airways, showed a significant correlation with the degree of airway obstruction in former or current smokers with COPD. However, AMPI in the peripheral airways was not correlated with the diffusing capacity of the lung in former or current smokers with COPD. Conclusion: Airway microvascular permeability in the peripheral airways is increased in patients with COPD, and is associated with the severity of airway obstruction. We may need to consider this characteristic feature as a target in any therapeutic strategy for the treatment of the disease. (237 words).