Synthesis of multiresponsive β‐cyclodextrin nanocomposite through surface RAFT polymerization for controlled drug delivery. (23rd July 2019)

• Record Type: Journal Article
• Authors: Hosseinzadeh, Hossein; Hosseinzadeh, Soleyman; Pashaei, Shahryar; Ghorbani, Naser; Mazaherpour, Rohollah
• Is Part Of: Polymers for advanced technologies. Volume 30:Number 11(2019)
• Page Start: 2860
• Page End: 2871
• Publication Date: 2019-07-23
• Subjects: doxorubicin -- drug delivery -- nanocomposite -- RAFT -- β‐Cyclodextrin; Polymers -- Periodicals; 668.9
• DOI: 10.1002/pat.4718
• Languages: English
• ISSNs: 1042-7147

Abstract

Abstract : In this study, a unique magnetic, pH, and thermo‐responsive hydrogel nanocomposite was synthesized via surface reversible addition fragmentation chain transfer (RAFT) copolymerization of acrylic acid (AA) and N‐isopropyl acrylamide (NIPAM) in the presence of magnetic β‐cyclodextrin (β‐CD). The nanocomposite demonstrated a pH‐responsiveness behavior at pHs 3 and 9. Moreover, swelling behaviors of nanocomposite were measured in solutions with various temperatures. Furthermore, the nanocomposites exhibited high swelling capacity by applying an external magnetic field because of the presence of Fe3 O4 nanoparticles in the polymer structure. Besides, the doxorubicin (DOX) loading and releasing behaviors of the hydrogel nanocomposites were studied because of the stimuli‐responsive properties of the synthesized carriers. The adsorption of DOX obeyed a pseudo‐second‐order model and fitted well to the Langmuir isotherm model with the maximum adsorption capacity uptake of 291 mg g −1 . In conclusion, the hydrogel nanocomposites were found to be as potential nanocarriers for use in controlled release applications.