Lobular neutrophilic panniculitis associated with DNA methyltransferase inhibitors in the treatment of myeloid disease. (26th August 2019)

• Record Type: Journal Article
• Authors: Coleman, Emily; Panse, Gauri; Cowper, Shawn; Prebet, Thomas; Gore, Steven; Leventhal, Jonathan
• Is Part Of: Journal of cutaneous pathology. Volume 46:Number 12(2019)
• Page Start: 930
• Page End: 934
• Publication Date: 2019-08-26
• Subjects: acute myelogenous leukemia -- DNA methyltransferase inhibitors -- lobular neutrophilic panniculitis; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616
• DOI: 10.1111/cup.13537
• Languages: English
• ISSNs: 0303-6987

Abstract

Abstract: Cutaneous toxicities to DNA methyltransferase inhibitors are variable and include localized injection site reactions, ecchymoses, maculopapular eruptions, and neutrophilic dermatoses including pyoderma gangrenosum, Sweet syndrome, and neutrophilic eccrine hidradenitis. This series describes two patients diagnosed with lobular neutrophilic panniculitis arising during treatment of acute myelogenous leukemia with "hypomethylating drugs, " including the first report of its occurrence with a next‐generation agent. Differential diagnoses, histopathologic characteristics, treatment considerations, and proposed pathogenesis will be discussed.