The effect of a face mask for respiratory support on breathing in preterm infants at birth. (November 2019)

• Record Type: Journal Article
• Authors: Kuypers, Kristel L.A.M.; Lamberska, Tereza; Martherus, Tessa; Dekker, Janneke; Böhringer, Stefan; Hooper, Stuart B.; Plavka, Richard; te Pas, Arjan B.
• Is Part Of: Resuscitation. Volume 144(2019)
• Page Start: 178
• Page End: 184
• Publication Date: 2019-11
• Subjects: CPAP Continuous positive airway pressure -- DR Diving reflex -- FiO2 Fraction of inspired oxygen -- GA Gestational age -- HR Heart rate -- LUMC Leiden University Medical Centre -- PEEP Positive end-expiratory pressure -- PPV Positive pressure ventilation -- RFM Respiratory function monitor -- SI Sustained inflation -- SpO2 Pulse oxygen saturation -- TCR Trigeminocardiac reflex; Preterm infants -- Breathing -- Face mask -- Trigeminocardiac reflex -- Respiratory support; Resuscitation -- Periodicals; Resuscitation -- Periodicals; Réanimation -- Périodiques; Electronic journals; 616.025
• DOI: 10.1016/j.resuscitation.2019.08.043
• Languages: English
• ISSNs: 0300-9572

Abstract

Abstract: Objective: Applying a mask on the face for respiratory support could induce a trigeminocardiac reflex leading to apnoea and bradycardia. We have examined the effect of applying a face mask on breathing and heart rate in preterm infants at birth. Methods: Resuscitation videos of infants ≤ 32 weeks gestation recorded from 2010 until 2018 at the Leiden University Medical Centre and the General University Hospital in Prague were reviewed. All infants received respiratory support via face mask. Breathing and heart rate were noted before and after application of the face mask and over the first 5 min. Results: Recordings of 429 infants were included (median (IQR) gestational age of 28 +6 (27 +1 -30 +4 ) weeks). In 368/429 (86%) infants breathing was observed before application of the face mask and 197/368 (54%) of these infants stopped breathing following application of the face mask. Apnoea occurred at a median of 5 (3–17) seconds after application of the face mask with a duration of 28 (22–34) seconds of the first minute. In a logistic regression model, the occurrence of apnoea after face mask application was inversely associated with gestational age (OR = 1.424 (1.281–1.583), p < 0.001). Infants who stopped breathing had a significantly lower heart rate 82 (66–123) vs 134 (97–151) bpm, p < 0.001) and oxygen saturation (49% (33–59) vs 66% (50–82), p < 0.001) over the first minute after face mask application, compared to infants who continued breathing. Conclusion: Applying a face mask for respiratory support affects breathing in a large proportion (54%) of preterm infants and this effect is gestational age dependent.